Literatura utilizada na aula teórica

Extraída de Biochemistry 5ª ed. e The Cell 4ª ed.

• Stryer, Cap 5. DNA, RNA, and the Flow of Genetic Information (figuras)
  1. A Nucleic Acid Consists of Four Kinds of Bases Linked to a Sugar-Phosphate Backbone
  2. A Pair of Nucleic Acid Chains with Complementary Sequences Can Form a Double-Helical Structure
  3. DNA Is Replicated by Polymerases that Take Instructions from Templates
  4. Gene Expression Is the Transformation of DNA Information Into Functional Molecules
  5. Amino Acids Are Encoded by Groups of Three Bases Starting from a Fixed Point
  6. Most Eukaryotic Genes Are Mosaics of Introns and Exons
  • Stryer, Cap 6. Exploring Genes
  1. The Basic Tools of Gene Exploration
  2. Recombinant DNA Technology Has Revolutionized All Aspects of Biology
  3. Manipulating the Genes of Eukaryotes
  4. Novel Proteins Can Be Engineered by Site-Specific Mutagenesis
• Stryer, Cap 27. DNA Replication, Recombination, and Repair (leitura complementar)
  1. DNA Can Assume a Variety of Structural Forms
  2. DNA Polymerases Require a Template and a Primer
  3. Double-Stranded DNA Can Wrap Around Itself to Form Supercoiled Structures
  4. DNA Replication of Both Strands Proceeds Rapidly from Specific Start Sites
  5. Double-Stranded DNA Molecules with Similar Sequences Sometimes Recombine (figuras)
  6. Mutations Involve Changes in the Base Sequence of DNA (figuras)
• Stryer, Cap 28. RNA Synthesis and Splicing
  1. Transcription Is Catalyzed by RNA Polymerase
  2. Eukaryotic Transcription and Translation Are Separated in Space and Time
  3. The Transcription Products of All Three Eukaryotic Polymerases Are Processed
  4. The Discovery of Catalytic RNA Was Revealing in Regard to Both Mechanism and Evolution (figuras)
• Stryer, Cap 29. Protein Synthesis (figuras) e leitura complementar
  1. Protein Synthesis Requires the Translation of Nucleotide Sequences Into Amino Acid Sequences
  2. Aminoacyl-Transfer RNA Synthetases Read the Genetic Code
  3. A Ribosome Is a Ribonucleoprotein Particle (70S) Made of a Small (30S) and a Large (50S) Subunit
  4. Protein Factors Play Key Roles in Protein Synthesis
  5. Eukaryotic Protein Synthesis Differs from Prokaryotic Protein Synthesis Primarily in Translation Initiation
• The Cell, Cap 12. Intracellular Compartments and Protein Sorting
  1. The Compartmentalization of Cells
  2. The Transport of Molecules between the Nucleus and the Cytosol
  3. The Transport of Proteins into Mitochondria and Chloroplasts
  4. Peroxisomes
  5. The Endoplasmic Reticulum
• The Cell, Cap 13 (leitura complementar somente). Intracellular Vesicular Traffic
  1. The Molecular Mechanisms of Membrane Transport and the Maintenance of Compartmental Diversity
  2. Transport from the ER through the Golgi Apparatus
  3. Transport from the Trans Golgi Network to Lysosomes
  4. Transport into the Cell from the Plasma Membrane: Endocytosis
  5. Transport from the Trans Golgi Network to the Cell Exterior: Exocytosis
• Stryer, Cap 4. Exploring Proteins (figuras)
  1. The Purification of Proteins Is an Essential First Step in Understanding Their Function
  2. Amino Acid Sequences Can Be Determined by Automated Edman Degradation
  3. Immunology Provides Important Techniques with Which to Investigate Proteins
  4. Peptides Can Be Synthesized by Automated Solid-Phase Methods
  5. Three-Dimensional Protein Structure Can Be Determined by NMR Spectroscopy and X-Ray Crystallography