1: Hum Mutat. 2004 Aug;24(2):112-9. 

OrthoDisease: a database of human disease orthologs.

O'Brien KP, Westerlund I, Sonnhammer EL.

Center for Genomics and Bioinformatics, Karolinska Institutet, Stockholm,
Sweden. kevobr@mbox.ki.se

One of the greatest promises of genome sequencing projects is to further the
understanding of human diseases and to develop new therapies. Model organism
genomes have been sequenced in parallel to human genomes to provide effective
tools for the investigation of human gene function. Many of their genes share a
common ancestry and function with human genes, and this is particularly true for
orthologous genes. Here we present OrthoDisease, a comprehensive database of
model organism genes that are orthologous to human disease genes. OrthoDisease
was constructed by applying the Inparanoid ortholog detection algorithm to
disease genes derived from the Online Mendelian Inheritance in Man database
(OMIM). Pairwise whole genome/proteome comparisons between Homo sapiens and six
other organisms were performed to identify ortholog clusters. OMIM numbers were
extracted from the OMIM Morbid Map and were converted to gene sequences using
the Locuslink mim2loc and loc2acc tables. These were mapped to Inparanoid
ortholog clusters using Blast. The number of ortholog clusters in OrthoDisease
with each respective species is currently: M. musculus, 1,354; D. melanogaster,
724; C. elegans, 533; A. thaliana, 398; S. cerevisiae, 290; and E. coli, 153.
The database is accessible online at http://orthodisease.cgb.ki.se, and can be
searched with disease or protein names. The web interface presents all ortholog
clusters that include a selected disease gene. A capability to download the
entire dataset is also provided. Copyright 2004 Wiley-Liss, Inc.

PMID: 15241792 [PubMed - indexed for MEDLINE]